I have two sample VBScript programs for updating the profile path for users
in bulk. These examples can be easily modified to update any single-valued
attribute of user objects. The programs are "Update User Profile" and
"Update User Profile 2" in this link:

http://www.rlmueller.net/freecode4.htm

In the first program the Excel spreadsheet has the Distinguished Names of
the users. The second example uses the NT Names (pre-Windows 2000 logon
name) instead.

To modify the "Telephone number" field on the "General" tab of ADUC, replace
profilePath with telephoneNumber throughout either example program. Other
techniques are required to update multi-valued attributes, but you can also
modify the numbers on the "Telephone" tab. For the attribute names, refer to
the first spreadsheet in this link:

http://www.rlmueller.net/UserAttributes.htm

Insufficient requirements.

Update what?

Do you want to read an MS-Excel worksheet with
Names and Phone Numbers and update the phone
numbers in a database table?  If so, what database?
Also, will each name correspond with a valid entry?